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        Research

        Clinical description and outcomes of Australian children with invasive group a streptococcal disease

        Invasive group A streptococcal infection in Australian children is frequently severe and has a high long-term morbidity burden ...

        Research

        Quality of life is poorly correlated to lung disease severity in school-aged children with cystic fibrosis

        There is no data exclusively on the relationship between health-related quality-of-life (HRQOL) and lung disease severity in early school-aged children with cystic fibrosis (CF). Using data from the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) we assessed the relationships between HRQOL, lung function and structure. ...

        Research

        Altered Behavior in Encephalitis: Insights From the Australian Childhood Encephalitis Study, 2013-2018

        Altered mental status is a major criterion for a diagnosis of encephalitis to be made with alteration in behavior, a key manifestation of altered mental status. We reviewed all evaluated cases identified by the Australian Childhood Encephalitis study between May 2013 and June 2018. ...

        Research

        ErbB4 in the brain: Focus on high grade glioma

        The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTKs) consists of EGFR, ErbB2, ErbB3, and ErbB4. These receptors play key roles in cell proliferation, angiogenesis, cell migration, and in some cases, tumor promotion. ...

        Research

        Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review

        Non-Aspergillus molds and non-albicans Candida contributed substantially to pediatric invasive fungal infection in our study ...

        Research

        Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement

        Consensus recommendations are outlined to direct preschool device design, test performance, and data analysis for the MBW technique ...

        Research

        The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology

        Our review highlights similarities and differences in the application of the test-negative design that deserve further examination ...

        Research

        The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia, 2013-2015

        Seasonal influenza is an important cause of acute neurological disease in Australian children. ...

        Research

        Nutritional Influences on Epigenetic Programming. Asthma, Allergy, and Obesity

        Reliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also... ...

        Research

        Lack of effectiveness of 13-valent pneumococcal conjugate vaccination against pneumococcal carriage density in Papua New Guinean infants

        Papua New Guinea (PNG) introduced the 13-valent pneumococcal conjugate vaccine (PCV13) in 2014, with administration at 1, 2, and 3 months of age. PCV13 has reduced or eliminated carriage of vaccine types in populations with low pneumococcal carriage prevalence, carriage density and serotype diversity. ...

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