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        Research

        The global epidemiology of impetigo: A systematic review of the population prevalence of impetigo and pyoderma

        We conducted a comprehensive, systematic review of the global childhood population prevalence of impetigo and the broader condition pyoderma. ...

        Research

        Changes in the clinical and epidemiological features of group A streptococcal bacteraemia in Australia's northern territory

        We aimed to measure the incidence and severity of invasive Group A Strep disease in the NT since 1996. ...

        Research

        Utility of auscultatory screening for detecting rheumatic heart disease in high-risk children in Australia's Northern Territory

        Sensitivity and positive predictive value of cardiac auscultation compared with echocardiography is poor, regardless of the expertise of the auscultator. ...

        Research

        FeBRILe3: Safety Evaluation of Febrile Infant Guidelines Through Prospective Bayesian Monitoring

        Despite evidence supporting earlier discharge of well-appearing febrile infants at low risk of serious bacterial infection (SBI), admissions for ≥48 hours remain common. Prospective safety monitoring may support broader guideline implementation. ...

        Research

        Pertussis immunisation in infancy and atopic outcomes: A protocol for a population-based cohort study using linked administrative data

        The burden of IgE-mediated food allergy in Australian born children is reported to be among the highest globally. This illness shares risk factors and frequently coexists with asthma, one of the most common noncommunicable diseases of childhood. ...

        Research

        Plasma cytokine profiles in very preterm infants with late-onset sepsis

        Very preterm infants have a marked innate inflammatory response at the time of late-onset sepsis ...

        Research

        Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis

        The aim of our study was to characterize the activity of TNAP on TLR agonists and assess the concentrations of plasma ALP during late-onset sepsis in newborns. ...

        Research

        High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear

        Both bacteria and viruses play a role in the development of acute otitis media, however, the importance of specific viruses is unclear. ...

        News & Events

        Institute celebrates eradication of rubella in Australia

        The eradication of rubella in Australia is evidence of the vital role vaccinations play in protecting our health, researchers at the Telethon Kids Institute say. ...

        Research

        Pneumococcal Conjugate Vaccines Are Protective Against Respiratory Syncytial Virus Hospitalizations in Infants: A Population-Based Observational Study

        Pneumococcal conjugate vaccines (PCV) reduced the risk of respiratory syncytial virus (RSV) in a randomized clinical trial. We aimed to assess the real-world effectiveness of PCV on RSV-hospitalizations among Western Australian infants. ...

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