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        Research

        Unpacking the complex nature of the autism epidemic

        This paper discusses changes in diagnostic criteria, decreasing age at diagnosis, improved case ascertainment, diagnostic substitution, and social influences. ...

        Research

        Increased longevity and the comorbidities associated with intellectual and developmental disability

        The contributors, all world experts in their fields, also discuss what we can learn from the presence of co-morbidities. ...

        Research

        Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function

        Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations. ...

        Research

        Early immunological influences on asthma development: opportunities for early intervention

        Early immunological influences on asthma development: opportunities for early intervention ...

        Research

        Hypoglycemia alarm enhancement using data fusion

        The acceptance of closed-loop blood glucose (BG) control using continuous glucose monitoring systems (CGMS) is likely to improve. ...

        Research

        Effects of simulated tidal and deep breathing on immature airway contraction to acetylcholine and nerve stimulation

        In adults, respiratory movements, such as tidal and deep breaths, reduce airway smooth muscle force and cause bronchodilation. ...

        Research

        Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells

        Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven... ...

        Research

        Adult psychosocial outcomes of children with specific language impairment, pragmatic language impairment and autism

        Evidence that some children also develop autistic symptomatology over time has raised suggestions that developmental language disorder... ...

        Research

        The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome

        Rett syndrome (RTT) is caused by mutations in the transcriptional repressor methyl CpG-binding protein 2 (MECP2). ...

        Research

        Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy

        Topical application of tumors with the TLR7 agonist imiquimod is an effective adjunct treatment for a range of primary dermatological cancers. ...

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