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        Research

        Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma model

        We established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model ...

        Research

        Using pneumococcal carriage studies to monitor vaccine impact in low- and middle-income countries

        We review the role of pneumococcal carriage studies for the evaluation of PCVs in LMICs and discuss optimal methods for conducting these studies ...

        Research

        Early life determinants of health: Invest early to break the cycle of long-term disadvantage in neurodevelopmental disorders

        This chapter discusses the importance of investment in early life determinants of health to break the cycle of long-term disadvantage. This chapter addresses these issues while focussing on neurodevelopmental disorders and their related mental health concerns as the targets at the centre of a biopsychosocial transformation of the health system. ...

        Research

        A framework for the management of the pediatric airway

        A simple, time critical, and pediatric-specific airway management approach will help to reduce airway-related pediatric morbidity and mortality ...

        Research

        Pre-exposure prophylaxis for HIV prevention during pregnancy and lactation: forget not the women and children

        The framework for appropriately identifying and managing at-risk pregnant and lactating women requiring PrEP is poorly defined ...

        Research

        A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment

        There is a marked shift in innate and adaptive immune responses in Chinese immigrants after living in a Western environment for several years ...

        Research

        Assessing Diversity in Early Childhood Development in the East Asia-Pacific

        In all six countries, child development scores increased with age and urban children consistently performed better than rural children ...

        Research

        Evaluation of a phased pneumococcal conjugate vaccine introduction in Mongolia using enhanced pneumonia surveillance and community carriage surveys

        The enhanced surveillance system in Mongolia will facilitate assessment of PCV13 impact on pneumonia, with radiological confirmed disease as the primary outcome ...

        Research

        Use of Continuous Glucose Monitoring Trends to Facilitate Exercise in Children with Type 1 Diabetes

        This study investigated the use of a carbohydrate intake algorithm based on continuous glucose monitoring trends during physical activity ...

        Research

        Explaining the evolution of ethnicity differentials in academic achievements: The role of time investments

        This paper is the first to explore whether differences in time use by children of Asian-born parents may help to explain the observed differentials in school achievements ...

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