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        Research

        No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa

        Previous studies have suggested that individuals recovered from anorexia nervosa (AN) are characterized by increased serotonergic (5-HT) activity that might be related to elevated levels of anxiety. Assuming these traits to be also present in individuals at risk for AN, it was further hypothesized that restricting food intake might be a means to temporarily alleviate dysphoric affective states by reducing central nervous availability of tryptophan (TRP), the sole precursor of 5-HT. ...

        Research

        Influenza vaccination among pregnant women in two hospitals in Sydney, NSW: what we can learn from women who decline vaccination

        Pregnant women are recognised as being at risk of serious illness from influenza. Despite this, and longstanding national recommendations for vaccination in pregnancy, vaccine uptake remains suboptimal. This study aims to determine factors associated with women declining influenza vaccination in pregnancy. ...

        Research

        CRISPR single base editing, neuronal disease modelling and functional genomics for genetic variant analysis: pipeline validation using Kleefstra syndrome EHMT1 haploinsufficiency

        Over 400 million people worldwide are living with a rare disease. Next Generation Sequencing identifies potential disease causative genetic variants. However, many are identified as variants of uncertain significance and require functional laboratory validation to determine pathogenicity, and this creates major diagnostic delays. ...

        Research

        Sleep Disordered Breathing and Recurrent Tonsillitis Are Associated With Polymicrobial Bacterial Biofilm Infections Suggesting a Role for Anti-Biofilm Therapies

        The underlying pathogenesis of pediatric obstructive sleep disordered breathing (SDB) and recurrent tonsillitis (RT) are poorly understood but need to be elucidated to develop less invasive treatment and prevention strategies. ...

        Research

        The early Human Capability Index (eHCI)

        Alanna Sincovich AS BPsych(Hons), PhD Senior Research Officer 08 6375 6108 Alanna.sincovich@telethonkids.org.au Senior Research Officer @ ...

        RHD Endgame Strategy

        RHD Endgame Strategy: Evidence Briefs 5 Priority Areas for Implementation Priority Action Areas Acknowledgements Increasing access to swimming pools ...

        Research

        The impact of Influenza infection during early life on immune development

        Deborah Strickland DH PhD Program Head, Immunobiology and Immunotherapeutic Program Deb.Strickland@telethonkids.org.au Program Head, Immunobiology ...

        News & Events

        Annual CRE Investigators' Meeting draws researchers from around the world

        Between 3rd - 5th May 2018, researchers from Australia, New Zealand, South Africa, and the United States (representing their Uganda collaboration) convened in Fremantle, Western Australia to attend the Strep A Spectrum Meetings: from Science to Strategy. ...

        Focus Area

        Early Environment

        The Early Environment research theme consists of four programs: Immunobiology and Immunotherapeutic, Early Life and Life Course Health, Infection and Vaccines, and End RHD. ...

        News & Events

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