Neonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Schistosomiasis japonica is an ancient parasitic disease that has severely impacted human health causing a substantial disease burden not only to the Chinese people but also residents of other countries such as the Philippines, Indonesia and, before the 1970s, Japan. Since the founding of the new People's Republic of China (P. R. China), effective control strategies have been implemented with the result that the prevalence of schistosomiasis japonica has decreased markedly in the past 70 years. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Among Australian adolescents, the 4CMenB vaccine had no discernible effect on the carriage of disease-causing meningococci, including group B ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Physical activity is essential for children’s healthy development, yet COVID-19 physical distancing restrictions such as school closures and staying at home, playground closures, and the cancelling of organised community sport have dramatically altered children’s opportunities to be physically active. This study describes changes in levels of physical activity and screen time from February 2020 (i.e., before COVID-19 restrictions were introduced in Western Australia) to May 2020 (i.e., when COVID-19 restrictions were in place). Parents of children aged 5 to 9 years from Western Australia were eligible to participate and recruited through convenience sampling. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

In 2019, the World Health Organization (WHO) flagged vaccine hesitancy as one of the top 10 threats to global health. The drivers of and barriers to under-vaccination include logistics (access to and awareness of affordable vaccines), as well as a complex mix of psychological, social, political, and cultural factors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Dengue has been a perennial public health problem in Medan city, North Sumatera, despite the widespread implementation of dengue control. Understanding the spatial and temporal pattern of dengue is critical for effective implementation of dengue control strategies. This study aimed to characterize the epidemiology and spatio-temporal patterns of dengue in Medan City, Indonesia. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

A biologically active vaccine may produce a low measured vaccine efficacy under a range of epidemiological, vaccine-related and logistical conditions ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

In the warmer tropical regions of WA no seasonality was observed, but overall incidence of LLC presentations were higher ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Severe hospitalized varicella still occurs with a 1-dose varicella program, although predominantly in unvaccinated children ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

Public health systems face tensions between individuals and the collective. Parents who selectively vaccinate demonstrate this tension ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019