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        Research

        Towards a diagnostic test for rheumatic fever

        Glenn Jonathan Michael Pat Tim Tobias Pearson Carapetis AM Serralha Holt Barnett Kollmann G JR MS PG TB TK BA (Education) PhD Candidate AM MBBS FRACP ...

        Research

        Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

        Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. ...

        Research

        Transiently increased IgE responses in infants and pre-schoolers receiving only (DTaP) vaccines compared to those initially receiving at least one dose of DTwP vaccine

        Confirm the generalised IgE-trophic activity of the DTaP vaccine in pre-schoolers and demonstrate similar (albeit transient) effects in infants ...

        Research

        Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis: a phase 1 open-label population pharmacokinetic study

        Since 1955, the recommended strategy for rheumatic heart disease secondary prophylaxis has been benzathine penicillin G injections administered intramuscularly every 4 weeks. Due to dosing frequency, pain, and programmatic challenges, adherence is suboptimal. It has previously been demonstrated that BPG delivered subcutaneously at a standard dose is safe and tolerable and has favorable pharmacokinetics, setting the scene for improved regimens with less frequent administration. ...

        Research

        Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

        Using prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin... ...

        Research

        Characterization of “bystander” effects of the diphtheria-pertussis-tetanus (DTP) vaccine on the IgE system

        Pat Tom Jonathan Holt Snelling Carapetis AM PG T JR PhD, DSc, FRCPath, FRCPI, FAA BMBS DTMH GDipClinEpid PhD FRACP AM MBBS FRACP FAFPHM PhD FAHMS ...

        News & Events

        Telethon Kids Institute research teams supported by WA Near-Miss Awards

        Seven important Telethon Kids Institute research projects have received support from the Future Health Research and Innovation Fund through the WA Near-Miss Awards (WANMA). ...

        Research

        Management of invasive group A streptococcal infections

        Invasive group A streptococcal disease in children includes deep soft tissue infection, bacteraemia, bacteraemic pneumonia, meningitis and osteomyelitis ...

        News & Events

        Why should all primary school aged kids get a free flu vaccine this winter?

        With COVID-19 being a major issue this year, is it still important to have a flu vaccine? And why have school aged children been included for a free vaccine? ...

        News & Events

        Nasal spray to prevent ear infections closer to fruition thanks to major grant

        A nasal spray that could potentially prevent childhood ear infections and reduce antibiotic use is a step closer to clinical trials thanks to a $500,000 CUREator grant. ...

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