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        Research

        Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

        Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

        Research

        Ovalbumin in breast milk is associated with a decreased risk of IgE-mediated egg allergy in children

        Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age ...

        Research

        Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study

        Epidemic viral infections predominated as causes of childhood encephalitis in Australia. The leading causes include vaccine-preventable diseases ...

        Research

        Comparative Postmarket Safety Profile of Adjuvanted and High-Dose Influenza Vaccines in Individuals 65 Years or Older

        The findings of this postmarketing assessment of the safety of 2 new enhanced influenza vaccines support confidence in ongoing vaccine use ...

        Research

        Invasive group A Streptococcus disease in Australian children: 2016 to 2018 - a descriptive cohort study

        Our aims were to describe the epidemiological distribution of paediatric invasive group A Streptococcus disease in Australia and correlate this with influenza notifications ...

        Research

        The dystroglycan receptor maintains glioma stem cells in the vascular niche

        These findings reveal a central role of the DG receptor, not only as a structural element, but also as a critical factor promoting mesenchymal-like GBM ...

        Research

        Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

        This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2017 influenza season ...

        Research

        Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

        Maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Taking a prebiotic approach to early immunomodulation for allergy prevention

        In this review we examine maternal and infant dietary sources of prebiotics with a particular focus on non-digestible oligosaccharides, which undergo SCFA. ...

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