The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Jenefer Timo Sarra Genevieve Jonathan Blackwell Lassmann Jamieson Syn Carapetis AM JM T SE GS JR BSc with First Class Honours, PhD, DSc, FMedSci, FAA ...

• 1. Telethon Kids Institute
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• Genetics and Health

The Global Symposium on Childhood Brain Tumours is bringing the world's premier childhood brain tumour researchers and scientists together in Perth. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2013
• February

The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2021
• February 2021

Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in hepatocytes ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2017
• October 2017

We show that vlincRNAs genes likely function in cis to activate nearby genes ...

• 1. Telethon Kids Institute
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• 2016
• January 2016

VEGFR-3 signaling plays a central role in lymphatic biology, both in the development of the lymphatic network during embryogenesis as well as in... ...

• 1. Telethon Kids Institute
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• 2015
• November 2015

Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.  ...

• 1. Telethon Kids Institute
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• 2024
• April 2024

We investigated the potential association of maternal coffee and tea consumption during pregnancy with childhood acute myeloid leukemia risk ...

• 1. Telethon Kids Institute
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• 2019
• October 2019

This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020