Sensitive measures of early lung disease are being integrated into therapeutic trials and clinical practice in cystic fibrosis (CF). The impact of early disease surveillance (EDS) using these novel and often intensive techniques on young children and their families is not well researched. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

In recent years the study of the commensal microbiota is driving a remarkable paradigm shift in our understanding of human physiology. However, intrinsic technical difficulties associated with investigating the Microbiomics of some body niches are hampering the development of new knowledge. This is particularly the case when investigating the functional role played by the human microbiota in modulating the physiology of key organ systems. A major hurdle in investigating specific Microbiome communities is linked to low bacterial density and susceptibility to bias caused by environmental contamination. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

With the deadly and highly transmissible SARS-CoV-2 virus causing the COVID-19 pandemic, there is global concern about the danger of contaminating healthcare workers (HCW), particularly during airway management of infected patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Our data suggest that FRC PC-CTs are less sensitive than TLC PC-CTs and that FB-CTs have similar sensitivity to PC-CTs in detecting lung disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

We demonstrate that NOTCH3 is a regulator of MUC5AC production ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Several lipid biomarkers of early cystic fibrosis lung disease were identified, which point toward potential disease monitoring and therapeutic approaches ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• November 2019

Human respiratory syncytial virus (RSV) remains the most common cause of severe lower respiratory tract disease amongst infants, and continues to cause annual epidemics of respiratory disease every winter worldwide. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Newborn screening (NBS) for cystic fibrosis (CF) provides an opportunity to commence management and therapeutic interventions significantly earlier ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

Preterm children have worse lung function than healthy controls ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016