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        Research

        Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study

        Epidemic viral infections predominated as causes of childhood encephalitis in Australia. The leading causes include vaccine-preventable diseases ...

        Research

        Functional validation of variants of unknown significance using CRISPR gene editing and transcriptomics: A Kleefstra syndrome case study

        There are an estimated > 400 million people living with a rare disease globally, with genetic variants the cause of approximately 80% of cases. Next Generation Sequencing (NGS) rapidly identifies genetic variants however they are often of unknown significance. ...

        Research

        Idiosyncratic nature of voriconazole photosensitivity in children undergoing cancer therapy

        In adults, the unpredictability of voriconazole pharmacokinetics, particularly in those patients receiving chemotherapy, is well recognised. A paucity of... ...

        Research

        Mental health problems among 4–17-year-olds with hearing problems: results from a nationally representative study

        Clinicians caring for children and young people with hearing problems should be alert for heightened risk of specific mental health problems based on age and the nature of hearing problems. ...

        Research

        The effect of endotracheal tubes versus laryngeal mask airways on perioperative respiratory adverse events in infants: A randomised controlled trial

        Evaluating the difference of the effects of Laryngeal mask airways compared to endotracheal tubes in older children (>1 year) in incidents of PRAE in infants. ...

        Research

        Probabilistic linkage of national immunisation and state-based health records for a cohort of 1.9 million births to evaluate Australia’s childhood immunisation program

        To describe the process for assembling a linked study that will enable the conduct of population-based studies related to immunisation and immunisation policy. ...

        Research

        Fetal alcohol spectrum disorder and youth justice: a prevalence study among young people sentenced to detention in Western Australia

        This study of young people in detention in Western Australia, has documented a high prevalence of FASD and severe neurodevelopmental impairment ...

        Research

        Older maternal age is associated with depression, anxiety, and stress symptoms in young adult female offspring

        Older maternal age is associated with depression, anxiety, and stress symptoms in young adult females ...

        Research

        Paediatric Active Enhanced Diseases Surveillance (PAEDS)

        Christopher Peter Tom Blyth Richmond Snelling CC PC T MBBS (Hons) DCH FRACP FRCPA PhD MBBS MRCP(UK) FRACP BMBS DTMH GDipClinEpid PhD FRACP Director, ...

        Research

        Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli

        We obtain a set of 57 candidate immediate early genes possessing promoters that consistently drive a rapid but transient increase in expression over time ...

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