Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Childcare centres will be invited to help boost children’s physical activity levels by signing on to a new program which commits them to creating more opportunities for physical activity. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2020
• November

Raelene Endersby R BSc (Hons) PhD Brainchild Fellow; Co-Head, Brain Tumour Research raelene.endersby@telethonkids.org.au Co-Head, Brain Tumour ...

• Telethon Kids Institute
• Projects

Using data from three large-scale genetic association studies we compared recruitment strategy and sample return rates. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

This study was the first to concurrently identify middle ear pathogens in both bacterial biofilm and intracellularly in the middle ear mucosa of children and to identify extensive DNA stranding in the MEF from children with AOM ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• December 2012

Advances in omics technologies have generated exponentially larger volumes of biological data; however, their analyses and interpretation are limited to computationally proficient scientists. We created OmicsVolcano, an interactive open-source software tool to enable visualization and exploration of high-throughput biological data, while highlighting features of interest using a volcano plot interface. In contrast to existing tools, our software and user-interface design allow it to be used without requiring any programming skills to generate high-quality and presentation-ready images. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from the ancestral bacterial ribosomes and feature dramatically reduced ribosomal RNAs. The structural basis of the mammalian mitochondrial ribosome assembly is currently not well understood. Here we present eight distinct assembly intermediates of the human large mitoribosomal subunit involving seven assembly factors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

This paper demonstrated that home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

In this investigation, the authors found an association between home pesticide exposure before birth and during a child's early years and acute lymphoblastic... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• December 2015