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        Research

        Oral prednisolone in preschool children with virus-associated wheeze: A prospective, randomised, double-blind, placebo-controlled trial

        Preschool children often have episodes of virus-associated wheeze and assessing efficacy of corticosteroids for paediatric wheeze exacerbations is inconcludsive ...

        Research

        Are scabies and impetigo “normalised”? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition

        Scabies and impetigo infections are under-recognised and hence under-treated by clinicians ...

        Research

        Population-based estimates of the effectiveness of pneumococcal vaccination in Australia

        Australia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide. ...

        Research

        Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

        Identified romidepsin as a promising therapeutic for mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia ...

        Research

        Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage

        This study helps us understand how cancer cells are regulated by key genes and their corresponding networks to alter their fate in response to specific... ...

        Research

        A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in children

        Acute lower respiratory infections (ALRI) are a major cause of hospitalisation in young children ...

        Facing the future: Giving kids in Tuvalu a better start as their country sinks into the sea

        Evaluating early childhood education in the villages of Northern Laos Northern Laos is a challenging place to run an education system. The ...

        Closing the Gap - Hitting ‘reset’ on how we measure early development in Aboriginal kids

        Closing the Gap Six Closing the Gap targets were created in 2008 in response to a call to achieve equality for Aboriginal and Torres Strait Islander ...

        Research

        CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural induction

        An estimated 3.5%-5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic delays of 5-30 years. Next-generation sequencing has improved clinical diagnostic rates to 33%-48%. In a majority of cases, novel variants potentially causing the disease are discovered.  ...

        Research

        Blinatumomab as bridging therapy in paediatric B-cell acute lymphoblastic leukaemia complicated by invasive fungal disease

        Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines recommend withholding chemotherapy to facilitate immune recovery in this setting, yet prolonged delays in leukaemia therapy increase risk of relapse. ...

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