Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

To explore the perceptions of parents who had a child or adolescent (6-18 years) diagnosed with a rare disease who attended a mainstream school in Western Australia. Design and methods: A cross-sectional online survey was conducted with 41 parents of children with a rare disease. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Tramadol is a bitter atypical opioid analgesic drug and is prescribed to treat postoperative pain in children. However, in many countries there is no licensed paediatric tramadol formulation available. We have formulated a novel chewable chocolate-based drug delivery system for the administration of tramadol to children. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022

Despite immense benefits of physical activity on health and developmental outcomes, few children achieve recommended daily levels of physical activity. Given more than half of families with children own a dog, we investigated the effect of a mobile health (mHealth) intervention to encourage dog-facilitated physical activity through increased family dog walking and children's active play with their dog. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Understanding immunity in humans to Group A Streptococcus (Strep A) is critical for the development of successful vaccines to prevent the morbidity and mortality attributed to Strep A infections. Despite decades of effort, no licensed vaccine against Strep A exists and immune correlates of protection are lacking; a major impediment to vaccine development. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss 'beneficial' exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

What's next Senior Research Officer Tepi McLaughlin, who is overseeing the expansion of Play Active, is working with the Telethon Kids Institute ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2022
• Collaboration

Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Francis Steve Mitrou Zubrick FG SR BEc FASSA, FAAMHS, MSc AM PhD Program Head, Population Health, and Team Head, Human Development and Community ...

• Telethon Kids Institute
• Projects

Multiple lifestyle risk factors exhibit a stronger association with non-communicable diseases (NCDs) compared to a single factor, emphasizing the necessity of considering them collectively. By integrating these major lifestyle risk factors, we can identify individuals with an overall unhealthy lifestyle, which facilitates the provision of targeted interventions for those at significant risk of NCDs. The aim of this study was to evaluate the socio-demographic correlates of unhealthy lifestyles among adolescents and adults in Ethiopia. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023