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        Research

        Temporal landscape of mitochondrial proteostasis governed by the UPRmt

        Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mitochondrial proteomes.  ...

        Research

        ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

        The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome requires separate enzymatic activities that can sterically compete, suggesting a life-long trade-off between these two processes. ...

        Research

        Robust and Interpretable General Movement Assessment Using Fidgety Movement Detection

        Fidgety movements occur in infants between the age of 9 to 20 weeks post-term, and their absence are a strong indicator that an infant has cerebral palsy. Prechtl's General Movement Assessment method evaluates whether an infant has fidgety movements, but requires a trained expert to conduct it. Timely evaluation facilitates early interventions, and thus computer-based methods have been developed to aid domain experts.  ...

        Research

        Protective Vaccine Responses in Infants after Maternal Pertussis Vaccination (PRIME) Study

        Christopher Jennifer Peter Blyth Kent Richmond CC J PC MBBS (Hons) DCH FRACP FRCPA PhD RN MBBS MRCP(UK) FRACP Director, Wesfarmers Centre of Vaccines ...

        Research

        The development and refinement of a sensitive bedside test to continually measure the severity of BPD and lung development in preterm infants

        Graham Jane Shannon Hall Pillow Simpson GL JP SS BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (Dist) MBBS, PhD (Dist) FRACP BMedSci (hons), PhD ...

        Research

        The effect of oral insulin on subcutaneous insulin requirements and glycaemia in T1DM

        Liz Tim Davis Jones EA TW MBBS FRACP PhD MBBS DCH FRACP MD Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity ...

        News & Events

        Alcohol labels a win for Australian babies

        Perth’s Telethon Kids Institute has praised the Food Safety Ministers of Australia and New Zealand for standing firm and putting children first by approving the recommended red, black and white mandatory warning label on alcohol products. ...

        News & Events

        Hon. Julie Bishop to join Human Vaccines Project board

        Telethon Kids Institute Chair Hon. Julie Bishop will join the international Human Vaccines Project’s Board of Directors on its mission to address the next frontier of human health – decoding the human immune system to transform how we prevent, diagnose and treat disease. ...

        News & Events

        Playgroup program transforms early learning in Tonga

        In Australia, community playgroups are seen as the ‘soft touch’. But a research project in Tonga is finding the benefits can last a lifetime. ...

        News & Events

        Making the right decision on air travel

        Professor Graham Hall is looking at the effect of air travel on premature babies, with his research already contributing to international guidelines. ...

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