A population of neutrophils recruited into cystic fibrosis (CF) airways is associated with proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker CD63 and reduced phagocytic receptor CD16. Causative factors for this population are unknown, limiting intervention. Here we present a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

It is the kids he treats in his role as a paediatric oncologist that motivate Dr Nick Gottardo in his work as a Telethon Kids Institute cancer researcher. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2015
• December

A study to investigate mental health and dietary patterns throughout childhood and into adolescence has received a $57,800 grant. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2007
• August

We sought to determine risk factors for the onset of bronchiectasis, using data collected by the Australian Respiratory Early Surveillance Team for Cystic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Parents interpreted pivotal vaccine-related events in the community as requiring them to take personal responsibility for vaccine decisions ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

No evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections in CF ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014