Gut microbiome patterns have been associated with predisposition to eczema potentially through modulation of innate immune signalling. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

A new study has found that the rate of caesarean sections in Western Australia has almost doubled in a 20 year period to 2003. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2007
• May

Early infancy oral vitamin D supplementation does not appear to reduce the development of early childhood allergic disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations in people with cystic fibrosis (CF). Outcomes used for evaluation should be meaningful; that is, they should capture how people feel, function or survive and be acknowledged as important to people with CF, or should be reliable surrogates of those outcomes. We aimed to summarise the outcomes and corresponding endpoints which have been reported in studies of pulmonary exacerbations, and to identify those which are most likely to be meaningful. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Treatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

There is a high incidence of vaccine-preventable morbidity post-allogeneic haematopoietic stem cell transplantation in West Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018