Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam in vitro and in vivo against diverse CPKp clinical isolates. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

A population of neutrophils recruited into cystic fibrosis (CF) airways is associated with proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker CD63 and reduced phagocytic receptor CD16. Causative factors for this population are unknown, limiting intervention. Here we present a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Few studies have evaluated the effect of maternal influenza vaccination on the development of allergic and autoimmune diseases in children beyond 6 months of age. We aimed to investigate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and subsequent diagnosis of allergic and autoimmune diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022

Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Parents interpreted pivotal vaccine-related events in the community as requiring them to take personal responsibility for vaccine decisions ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Restricted antimicrobials acquired after-hours are not routinely antimicrobial stewardship adherent at the time of acquisition or the next standard working day ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Understanding informant discrepancies and their meaning is pivotal to designing surveys that generate robust insights into the health of sexual-minority adolescents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Agreement between the DDD and vial-based measures of use supports the use of DDD for select antibiotics that may be targeted by antimicrobial stewardship programs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019