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        Research

        The safety and feasibility of the inhaled mannitol challenge test in young children

        Mannitol challenge tests are used clinically to diagnose asthma and, in particular, exercise-induced broncoconstriction (EIB) in adults and children above 6... ...

        Research

        Expiratory flow limitation and breathing strategies in overweight adolescents during submaximal exercise

        Young people who are overweight/obese are more likely to display expFL during submaximal exercise compared with children of healthy weight. ...

        Research

        Characterization of maximal respiratory pressures in healthy children

        Measurements of maximal voluntary inspiratory (Pi max) and expiratory (Pe max) pressures are used in the management of respiratory muscle disease... ...

        Research

        Infection, inflammation,and lung function decline in infants with cystic fibrosis

        Better understanding of evolution of lung function in infants with cystic fibrosis... ...

        Research

        A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in children

        Acute lower respiratory infections (ALRI) are a major cause of hospitalisation in young children ...

        Research

        Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Graham Stephen Hall Stick GL SM BAppSci PhD CRFS FANZSRS FThorSoc FERS MB BChir PhD MRCP FRACP Honorary Research Associate Head, P4 Respiratory ...

        Research

        Protocol for spatial prediction of soil transmitted helminth prevalence in the Western Pacific region using a meta-analytical approach

        Soil transmitted helminth infections are estimated to impact 24% of the world's population and are responsible for chronic and debilitating morbidity. Disadvantaged communities are among the worst affected and are further marginalized as infection prevalence fuels the poverty cycle. ...

        Research

        Strep A: challenges, opportunities, vaccine-based solutions and economics

        Streptococcus pyogenes (Strep A) is a leading cause of morbidity and mortality across the globe, annually causing hundreds of millions of cases of disease. ...

        Research

        Increased levels of solar radiation are associated with reduced type-2 diabetes prevalence: A cross-sectional study of Australian postcodes

        Type-2 diabetes is a leading cause of death and disability. Emerging evidence suggests that ultraviolet radiation or sun exposure may limit its development. We used freely available online datasets to evaluate the associations between solar radiation and type-2 diabetes prevalence across Australia. ...

        Research

        Differential DNA methylation of steatosis and non-alcoholic fatty liver disease in adolescence

        Epigenetic modifications are associated with hepatic fat accumulation and non-alcoholic fatty liver disease (NAFLD). However, few epigenetic modifications directly implicated in such processes have been identified during adolescence, a critical developmental window where physiological changes could influence future disease trajectory. To investigate the association between DNA methylation and NAFLD in adolescence, we undertook discovery and validation of novel methylation marks, alongside replication of previously reported marks. ...

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