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        Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria

        Individual-based models have become important tools in the global battle against infectious diseases, yet model complexity can make calibration to biological and epidemiological data challenging. We propose using a Bayesian optimization framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator. ...

        Research

        Racism and Indigenous Adolescent Development: A Scoping Review

        Previous studies on the impacts of racism on adolescent development have largely overlooked Indigenous youth. We conducted a scoping review of the empirical literature on racism against Indigenous adolescents to determine the nature and scope of this research and to establish associations with developmental outcomes. ...

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        Identifying individual, household and environmental risk factors for malaria infection on Bioko Island to inform interventions

        Since 2004, malaria transmission on Bioko Island has declined significantly as a result of the scaling-up of control interventions. The aim of eliminating malaria from the Island remains elusive, however, underscoring the need to adapt control to the local context. Understanding the factors driving the risk of malaria infection is critical to inform optimal suits of interventions in this adaptive approach. ...

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        Associations between school absence and academic achievement: Do socioeconomics matter?

        School attendance should therefore be a priority for all schools, and not just those with high rates of absence or low average achievement. ...

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        Ontogeny of toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants

        Studies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in... ...

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        Dr Nelly Amenyogbe

        Microbiome Research Fellow ...

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        Research

        Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea

        We aimed to explore whether newborns in high-risk areas have pre-existing pneumococcal-specific cellular immune responses that effects early acquisition. ...

        Research

        Australian Study of Causes of Acute Lymphoblastic Leukaemia in Children

        Liz Carol Ursula Milne Bower Kees E C UR MPH PhD MBBS MSc PhD FAFPHM DLSHTM FPHA PhD Honorary Emeritus Fellow Senior Principal Research Fellow, ...

        Research

        Malaria components of the Global Burden of Disease study

        Adam Dan Francesca Paulina Susan Tara Saddler Weiss Sanna Dzianach Rumisha Boyhan AS DW FS PD SR TB PhD PhD Dr MA PhD (Biostatistics) Research ...

        Research

        Off-target effects of bacillus Calmette-Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19

        Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19). ...

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