This study was the first to concurrently identify middle ear pathogens in both bacterial biofilm and intracellularly in the middle ear mucosa of children and to identify extensive DNA stranding in the MEF from children with AOM ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• December 2012

Raelene Endersby R BSc (Hons) PhD Brainchild Fellow; Co-Head, Brain Tumour Research raelene.endersby@telethonkids.org.au Co-Head, Brain Tumour ...

• Telethon Kids Institute
• Projects

Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from the ancestral bacterial ribosomes and feature dramatically reduced ribosomal RNAs. The structural basis of the mammalian mitochondrial ribosome assembly is currently not well understood. Here we present eight distinct assembly intermediates of the human large mitoribosomal subunit involving seven assembly factors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Advances in omics technologies have generated exponentially larger volumes of biological data; however, their analyses and interpretation are limited to computationally proficient scientists. We created OmicsVolcano, an interactive open-source software tool to enable visualization and exploration of high-throughput biological data, while highlighting features of interest using a volcano plot interface. In contrast to existing tools, our software and user-interface design allow it to be used without requiring any programming skills to generate high-quality and presentation-ready images. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

In this investigation, the authors found an association between home pesticide exposure before birth and during a child's early years and acute lymphoblastic... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• December 2015

This paper demonstrated that home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

It may surprise you to know that the Australian government has invested almost $300 million dollars since 2000 towards research and clinical trials for diabetes ...

• Rio Tinto Children's Diabetes Centre
• News and events
• Diabetes news and events
• Summer 2015

Quick facts The Built Environments and Child Health in Wales and Australia (BEACHES) project aims to provide evidence about how built environments ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2022
• Collaboration

High-grade gliomas including glioblastoma (GBM) and diffuse midline gliomas (DMG) represent the most lethal and aggressive brain cancers where current treatment modalities offer limited efficacy. Chimeric antigen receptor (CAR) T cell therapies have emerged as a promising strategy, boasting tumor-specific targeting and the unique ability to penetrate the blood-brain barrier. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• August 2024