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        Research

        Illuminating mitochondrial translation through mouse models

        Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial genome encodes 11 mRNAs encoding 13 OXPHOS proteins along with 2 rRNAs and 22 tRNAs, that facilitate their translation on mitoribosomes. ...

        Research

        EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses

        High-grade gliomas including glioblastoma (GBM) and diffuse midline gliomas (DMG) represent the most lethal and aggressive brain cancers where current treatment modalities offer limited efficacy. Chimeric antigen receptor (CAR) T cell therapies have emerged as a promising strategy, boasting tumor-specific targeting and the unique ability to penetrate the blood-brain barrier. ...

        Partnering with government to influence policy and practice

        Quick facts The Built Environments and Child Health in Wales and Australia (BEACHES) project aims to provide evidence about how built environments ...

        Research

        Preventative therapeutic approaches for hypertrophic cardiomyopathy

        Sarcomeric gene mutations are associated with the development of hypertrophic cardiomyopathy (HCM). Current drug therapeutics for HCM patients are effective in relieving symptoms, but do not prevent or reverse disease progression. Moreover, due to heterogeneity in the clinical manifestations of the disease, patients experience variable outcomes in response to therapeutics. ...

        Research

        The FASTK family proteins fine-tune mitochondrial RNA processing

        Transcription of the human mitochondrial genome and correct processing of the two long polycistronic transcripts are crucial for oxidative phosphorylation. According to the tRNA punctuation model, nucleolytic processing of these large precursor transcripts occurs mainly through the excision of the tRNAs that flank most rRNAs and mRNAs. ...

        Research

        Reviewing the Pathogenic Potential of the Otitis-Associated Bacteria Alloiococcus otitidis and Turicella otitidis

        There is insufficient evidence available to determine whether these organisms are pathogens, commensals or contribute indirectly to the pathogenesis of OM ...

        News & Events

        Harvard Professor captivates at Annual Community Lecture

        Professor Bloom used his time to make a powerful case for the idea that 'healthier means wealthier' at the Telethon Kids Annual Community Lecture for 2017 ...

        Research

        BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis

        Bacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects. ...

        News & Events

        New research into Vitamin D and Sunlight has created Project D-Light

        Project D-Light aims to understand and harness the benefits of vitamin D and sunlight for Australian children while protecting them from excess UV. ...

        Case Study: Maia Financial

        Procurement and Supply Partner Queries Corporate Philanthropy For any procurement queries, please contact the Institute's Procurement Team. Emma ...

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