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        Research

        Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response

        Vaccination to prevent infectious disease is one of the most successful public health interventions ever developed. And yet, variability in individual vaccine effectiveness suggests that a better mechanistic understanding of vaccine-induced immune responses could improve vaccine design and efficacy. ...

        Research

        Study protocol for Healthy Conversations @ Playgroup: a multi-site cluster randomized controlled trial of an intervention to promote healthy lifestyle behaviours in young children attending community playgroups

        Early childhood is a critical window for preventing obesity and chronic disease. Yet, 1 in 4 Australian children aged 5 years and under are affected by overweight or obesity; and significant proportions of children under 5 years fail to meet guidelines for diet quality, physical activity (PA), screen time, and sleep. ...

        Research

        A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance

        Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the MRPP3 gene, which encodes a mitochondrial RNA processing enzyme within the RNase P complex, with predicted impact on metabolism. We used CRISPR-Cas9 genome editing to introduce this variant into the mouse Mrpp3 gene and show that the variant causes insulin resistance on a high-fat diet. ...

        Research

        One vaccine for life: Lessons from immune ontogeny

        There remains a general misconception that the immune status of the fetus and neonate is immature or insufficient. However, emerging research in immune ontogeny prompts reconsideration of this orthodoxy, reframing this period instead as one of unique opportunity. Vaccine responses (qualitative and quantitative) vary between individuals, and across demographic cohorts. Elements of baseline immune status and function predict vaccine response - some of these factors are well described, others remain a subject of ongoing research, especially with the rapidly expanding field of 'omics' research, enabled by development of highly granular immune profiling techniques and increasing computational capacity. ...

        Research

        The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation

        Despite significant progress in reaching some milestones of the United Nations Sustainable Development Goals, neonatal and early infant morbidity and mortality remain high, and maternal health remains suboptimal in many countries. Novel and improved preventative strategies with the potential to benefit pregnant women and their infants are needed, with maternal and neonatal immunization representing effective approaches. ...

        Quality of Life in Disability

        Study: Quality of Life Researchers at the Telethon Kids Institute are asking parents of school-aged children with Down syndrome to complete a ...

        News & Events

        Powerful new network to ensure Indigenous Australians can benefit from genomic medicine

        A national alliance of the brightest minds in genomic science, academia, policy makers, industry and Indigenous leaders will work to break down barriers to ensure Aboriginal and Torres Strait Islander people can benefit from advances in genomic medicine if they choose. ...

        News & Events

        Major conference tackles FASD from the head and the heart

        Hundreds of delegates from around Australia, Canada and New Zealand arrive in Perth this week to discuss the latest knowledge about fetal alcohol spectrum disorder (FASD) at the 2nd Australasian FASD Conference 2018. ...

        News & Events

        Telethon Kids welcomes State Government commitment to research

        Telethon Kids Institute, has welcomed the State Government's budget commitment to innovation and medical research. ...

        News & Events

        Hospital: Don't keep kids away

        Doctors are urging parents not to risk their child becoming seriously ill by avoiding taking them to hospital or a GP surgery because of coronavirus. Story by The West Australian featuring Professor Liz Davis. ...

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