We are delighted to share that Telethon Kids has successfully completed its Athena SWAN Bronze Action Plan. ...

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• Gender Equity, Diversity, and Inclusivity

It was the right story at the right time: six months into COVID-19, as the world was reeling from the relentless blows of a ballooning pandemic, ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2021
• Research translation

The epithelium is integral to the protection of many different biological systems and for the maintenance of biochemical homeostasis. Emerging evidence suggests that particular children have epithelial vulnerabilities leading to dysregulated barrier function and integrity, that resultantly contributes to disease pathogenesis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Medulloblastoma is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Transcription factors known to induce the epithelial-to-mesenchymal transition (EMT) (such as ZEB1/2 [zinc finger E-box binding homeobox 1/2], SNAI1/2/3, and TWIST1/2) have been undoubtedly implicated in tumorigenesis, cancer progression, metastasis, and chemoresistance in solid tumors; however, their role in normal and malignant hematopoiesis has been underappreciated for many years. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research ...

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Nick Raelene Gottardo Endersby NG R MBChB FRACP PhD BSc (Hons) PhD Co-Head, Brain Tumour Research Brainchild Fellow; Co-Head, Brain Tumour Research ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma-extracellular signal-regulated kinase-MAPK significant pathway, leading to cellular proliferation, survival, and dedifferentiation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

Honorary Research Associate ...

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Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023