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        Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial

        Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents. The aim of this trial was to assess the effectiveness of affordable, widely available, repurposed drugs used in combination for treatment of COVID-19, which may be particularly relevant to low-resource countries.  ...

        Research

        Risk factors and comorbidities for invasive pneumococcal disease in Western Australian Aboriginal and non-Aboriginal people

        Australian Aboriginal people have among the highest rates of invasive pneumococcal disease (IPD) worldwide. This paper investigates clinical diagnosis, risk... ...

        Research

        Parental Tdap boosters and infant pertussis: a case-control study

        Case households had fewer immunized mothers (22% vs 32%) or fathers (20% vs 31%) but were more likely to include additional and older children. After... ...

        Research

        Predictors of Disease Severity in Children Hospitalized for Pertussis during an Epidemic

        This study aimed to determine factors associated with severe pertussis in hospitalized children during an epidemic using a novel pertussis severity scoring... ...

        Research

        Febrile seizures following measles and varicella vaccines in young children in Australia

        Febrile seizures (FS) are common in childhood with incidence peaking in the second year of life when measles and varicella-containing vaccines are administered. ...

        Research

        Characterization of G2P[4] rotavirus strains causing outbreaks of gastroenteritis in the Northern Territory, Australia, in 1999, 2004 and 2009

        Outbreaks of rotavirus diarrhea cause a large disease burden in the Alice Springs region of the Northern Territory, Australia. ...

        Research

        Establishing a process for conducting cross-jurisdictional record linkage in Australia

        We outline the processes involved in conducting a Proof of Concept data linkage project including the implementation of national data integration principles ...

        Research

        Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015

        This paper reports the results from the safety surveillance of influenza vaccines in children in Australia, in 2015. ...

        Research

        Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination

        Early 7vPCV schedules have limited impact on pneumococcal vaccine type carriage in PNG ...

        Research

        Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia.

        This study aimed to acquire nationally representative epidemiological data on GAS in Australia to scope the appropriate age for vaccination with a potential... ...

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