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        Research

        Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)

        Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. ...

        Research

        Treatment Outcomes among Pregnant Patients with Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis

        The management of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes. ...

        Research

        School bullying: moving beyond a single school response to a whole education approach

        Bullying is an issue that continues to represent a significant challenge to the provision of pastoral care in schools. In more recent decades, it has evolved in its complexity to include forms of bullying often referred to as cyberbullying or online bullying. ...

        Research

        Factors influencing the attainment of major motor milestones in CDKL5 deficiency disorder

        This study investigated the influence of factors at birth and in infancy on the likelihood of achieving major motor milestones in CDKL5 Deficiency Disorder (CDD). Data on 350 individuals with a pathogenic CDKL5 variant was sourced from the International CDKL5 Disorder Database. ...

        Research

        Unusual 2020 respiratory syncytial virus bronchiolitis season in Western Australia: Not explained by weather

        To describe and explore the relationship between weather and the unusual 2020 bronchiolitis season in Western Australia during the COVID-19 pandemic. ...

        Research

        Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

        Recent evidence suggests that burn patients are at increased risk of hospital admission for infection, mental health conditions, cardiovascular disease and cancer for many years after discharge for the burn injury itself. ...

        Research

        Reducing exacerbations in children and adults with primary ciliary dyskinesia using erdosteine and/or azithromycin therapy (REPEAT trial): study protocol for a multicentre, double-blind, double-dummy, 2×2 partial factorial, randomised controlled trial

        Primary ciliary dyskinesia (PCD) is a rare, progressive, inherited ciliopathic disorder, which is incurable and frequently complicated by the development of bronchiectasis. There are few randomised controlled trials (RCTs) involving children and adults with PCD and thus evidence of efficacy for interventions are usually extrapolated from people with cystic fibrosis. ...

        Research

        Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium

        Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia and acute myeloid leukemia. However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. ...

        Research

        Racism and Indigenous Adolescent Development: A Scoping Review

        Previous studies on the impacts of racism on adolescent development have largely overlooked Indigenous youth. We conducted a scoping review of the empirical literature on racism against Indigenous adolescents to determine the nature and scope of this research and to establish associations with developmental outcomes. ...

        Research

        The Centres for Disease Control light trap and the human decoy trap compared to the human landing catch for measuring Anopheles biting in rural Tanzania

        Vector mosquito biting intensity is an important measure to understand malaria transmission. Human landing catch (HLC) is an effective but labour-intensive, expensive, and potentially hazardous entomological surveillance tool. The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) are exposure-free alternatives. ...

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