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        Research

        Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathways

        Our results provide a possible functional link between Toxoplasma gondii infection and congenital/early life and adult neurological clinical signs ...

        Research

        Newborn Nasal Sampling Evaluation (NOSE) Study

        Desiree Stephen Susan Silva Stick Prescott DS SM SL MBBS, FRACP, MPH, PhD MB BChir PhD MRCP FRACP MBBS BMedSci PhD FRACP Co-Head, The ORIGINS Project ...

        News & Events

        Four Telethon Kids Institute research leaders named as finalists for West Australian of the Year Awards

        Four outstanding members of the Telethon Kids Institute family have been named as finalists in the 2024 Western Australian of the Year Awards. ...

        Research

        Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease Outcomes

        Infant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects. ...

        Research

        Association Between Family Characteristics and the Effect of Timing of Regular Egg Introduction in Infant Egg Allergy

        A recent systematic review of 5 randomized clinical trials, found that early egg introduction was associated with reduced egg allergy. ...

        Research

        Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

        We compared neonatal T reg from children born in western conditions (Australia) with those of neonates born in high microbial conditions (Papua New Guinea)... ...

        Research

        Uplift: Online self-compassion training for young people with chronic conditions

        Amy Yael Asha Finlay-Jones Perry Parkinson AFJ YP AP BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) BPsych (Hons) MPsych (Clin) PhD ...

        News & Events

        Directing immune development to curb sky-rocketing disease

        Once upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism. ...

        News & Events

        Celebrating 25 years

        As our Founding Director Fiona Stanley puts it, The Telethon Kids Institute was formed on a "wing and a prayer". ...

        Research

        Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease

        Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of uncertain significance (VUS). Functional analysis of each VUS is required in specialised laboratories, to determine whether the VUS is disease causative or not, leading to lengthy diagnostic delays. ...

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