2020 Saw RSV Rates Rollercoaster – Scientists are still working out why Baby George joins the RSV fight Winter typically brings a surge in ...

• Telethon Kids Institute
• Our research
• Research Impact
• 2021
• In the pipeline

Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Perth parents are underestimating the serious consequences of the flu, with only 19 per cent of children under five years of age currently immunized against the virus ahead of the peak winter flu season. ...

• Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2018
• August

Bacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Australian children and adolescents were among the last local cohorts offered COVID-19 vaccines. Despite promising initial uptake, coverage subsequently plateaued, requiring further efforts to improve access and build parents’ recognition of the importance of COVID-19 vaccination. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

Rheumatic heart disease (RHD) is a chronic cardiac condition with an infectious aetiology, causing high disease burden in low-income settings. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

This trial aims to improve uptake of secondary prophylaxis among Aboriginal people with ARF/RHD to reduce progression or worsening of RHD. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016