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        Research

        Single-cell transcriptomic and spatial landscapes of the developing human pancreas

        Current differentiation protocols have not been successful in reproducibly generating fully functional human beta cells in vitro, partly due to incomplete understanding of human pancreas development. Here, we present detailed transcriptomic analysis of the various cell types of the developing human pancreas, including their spatial gene patterns. We integrated single-cell RNA sequencing with spatial transcriptomics at multiple developmental time points and revealed distinct temporal-spatial gene cascades. ...

        Research

        Rare disease education in Europe and beyond: time to act

        People living with rare diseases (PLWRD) still face huge unmet needs, in part due to the fact that care systems are not sufficiently aligned with their needs and healthcare workforce (HWF) along their care pathways lacks competencies to efficiently tackle rare disease-specific challenges. Level of rare disease knowledge and awareness among the current and future HWF is insufficient. ...

        Households with total income < $1000 per week

        Policy Context Indicator Information View the Maps Low income households are households that are in the lowest 18% of equivalised disposable ...

        Allergies

        Match the Allergens Food Allergies Colouring In Playdough Dust Mites An allergy is when a person is very sensitive to something that is harmless for ...

        Research

        Strategies for coping and dealing with lateral violence among Aboriginal people living in south-east Australia

        Lateral violence, a group of behaviours directed towards people of the same group, is considered endemic among Aboriginal people. Behaviours include bullying, gossiping, isolation or exclusion of certain group members, and challenges to one’s Aboriginal identity. Lateral violence impacts all aspects of one’s life. Due to its pervasiveness, this qualitative study investigated strategies employed by Aboriginal people to deal with lateral violence. ...

        Research

        Supporting nutrition education in low socioeconomic schools in Western Australia

        School-based nutrition education (NE) has an important role in promoting healthy eating habits and helping prevent chronic diseases – particularly among disadvantaged children and youth who are more likely to experience poor diet quality.  ...

        Research

        Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways

        nfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation.  ...

        Research

        Wongi mi bardup (doing it our way): Methodologies promoting Aboriginal knowledges and cultural practices for Birthing on Noongar Boodjar

        This paper sets out the methodological and theoretical considerations which framed how the Birthing on Noongar Boodjar project was conducted ...

        Research

        The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia

        Despite knowledge about excess mortality in people with mental illness, the gap in their life expectancy compared with the general population has widened... ...

        Research

        Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

        Genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment ...

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