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        Research

        CrossTalk opposing view: Mucosal acidification does not drive early progressive lung disease in cystic fibrosis

        Whether airway mucosal acidification drives early progressive lung disease is controversial ...

        Research

        Sustained participation in annual continuous quality improvement activities improves quality of care for Aboriginal and Torres Strait Islander children

        To determine whether participation in the CQI Audit and Best Practice for Chronic Disease programme improved care and outcomes for Indigenous children. ...

        Research

        Accuracy of self-reported private health insurance coverage

        Studies on health insurance coverage often rely on measures self-reported by respondents, but the accuracy of such measures has not been thoroughly validated. This paper is the first to use linked Australian National Health Survey and administrative population tax data to explore the accuracy of self-reported private health insurance (PHI) coverage in survey data. ...

        Research

        Supporting parents with young children to create healthy screen time behaviours

        Mary Amy Gina Bec Brushe Finlay-Jones Trapp Young MB AFJ GT BY BPsych(Hons), PhD (Public Health) BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD ( ...

        Research

        Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells

        This study assessed an alternative approach, using a small scale halide assay that can be adapted for a personalized high throughput setting to analyze CFTR function of pAEC. ...

        Research

        Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair.

        The airway epithelium of both children and adults with asthma is relatively undifferentiated characterized by a significantly increased proportion of... ...

        Research

        BEAT CF pulmonary exacerbations core protocol for evaluating the management of pulmonary exacerbations in people with cystic fibrosis

        Cystic fibrosis (CF) is a rare, inherited, life-limiting condition predominantly affecting the lungs, for which there is no cure. The disease is characterized by recurrent pulmonary exacerbations (PEx), which are thought to drive progressive lung damage. Management of these episodes is complex and generally involves multiple interventions targeting different aspects of disease. The emergence of innovative trials and use of Bayesian statistical methods has created renewed opportunities for studying heterogeneous populations in rare diseases. ...

        Research

        Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

        This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells ...

        Research

        Azithromycin Partially Mitigates Dysregulated Repair of Lung Allograft Small Airway Epithelium

        Chronic airway injury and dysregulated repair programs are evident in airway epithelium obtained from patients with bronchiolitis obliterans syndrome ...

        News & Events

        International clinical trial reduced lung inflammation in young kids with cystic fibrosis

        Promising results from an Australian-led clinical trial could drastically change the way we care for young children with cystic fibrosis (CF). ...

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