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        Research

        CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy

        While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tumors before and after cyclophosphamide, and compare the gene expression profiles of responders with progressors. ...

        Research

        Meeting the Australian 24-Hour Movement Guidelines for the Early Years is associated with better social-emotional development in preschool boys

        24-hour Movement Guidelines for the Early Years promote that achieving all three-movement behaviour (sleep, sedentary behaviour and physical activity) recommendations is important for child health and development. We examined the association between meeting all, none and combinations of the Australian 24-Hour Movement Guidelines for the Early Years and social-emotional development in 1363 preschool (2-5 years) boys (52%) and girls. ...

        Research

        Occurrence of psychosis and bipolar disorder in adults with autism: A systematic review and meta-analysis

        Evidence suggests that individuals with autism spectrum disorder have increased rates of co-occurring psychosis and/or bipolar disorder. Considering the peak age of onset for psychosis and bipolar disorder occurs in adulthood, we investigated the co-occurrence of these disorders in adults with autism. ...

        Research

        The evolution of local food environments within established neighbourhoods and new developments in Perth, Western Australia

        People living in new developments, and low SES areas of Perth, may be disadvantaged with poorer access to healthy food and greater exposure to unhealthy food outlets ...

        Research

        Shade coverage, ultraviolet radiation and children’s physical activity in early childhood education and care

        The provision of shade, particularly through natural forms such as tree canopy, is an important sun protection strategy and enabler of outdoor time ...

        Research

        Online self-compassion training to improve the wellbeing of youth with chronic medical conditions: Protocol for a randomised control trial

        The Self-Compassion Online program could provide a scalable solution for improving psychological outcomes and quality of life among youth with chronic illness ...

        Research

        Childhood Overweight and Obesity: Maternal and Family Factors

        The need to target prevention and intervention efforts for childhood overweight and obesity towards families with overweight parents ...

        Research

        Mapping mammalian cell-type-specific transcriptional regulatory networks using KD-CAGE and ChIP-seq data in the TC-YIK cell line.

        Examining the overlap between genes perturbed in the KD-CAGE experiments and genes with a ChIP-seq peak within 50 kb of their promoter, we identified direct... ...

        Research

        Age at surgery and outcomes of an undescended testis

        We investigated the prevalence of UDT and examined rates of surgery and age at surgery in an Australian population. ...

        Research

        The psychosocial burden of childhood overweight and obesity: evidence for persisting difficulties in boys and girls

        Overweight and obese children reported greater psychosocial distress than healthy weight children, and these differences were more pronounced for girls than boys. ...

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