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        Research

        Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child

        Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways ...

        Research

        Onset of maternal psychiatric disorders after the birth of a child with autism spectrum disorder: A retrospective cohort study

        Mothers of a child with autism spectrum disorder have more psychiatric disorders after the birth of their child. ...

        Research

        Moving beyond behaviour-only assessment: Incorporating biomarkers to improve the early detection and diagnosis of autism spectrum disorders

        This paper presents a response to the Camarata (2014) lead article regarding the accuracy and effectiveness of early identification and early intervention... ...

        Research

        High use of complementary and alternative medication among children with autism is not associated with the severity of core symptoms

        This study provided evidence for high rate of alternative medicine use in an Australian paediatric ASD population, similar to other countries. ...

        Research

        The effect of oxytocin nasal spray on social interaction in young children with autism: a randomized clinical trial

        Early supports to enhance social development in children with autism are widely promoted. While oxytocin has a crucial role in mammalian social development, its potential role as a medication to enhance social development in humans remains unclear. ...

        Research

        Dental procedures in children with or without intellectual disability and autism spectrum disorder in a hospital setting

        This population-based cohort study investigated dental procedures in the hospital setting in Western Australian children with or without intellectual disability (ID) and/or autism spectrum disorder (ASD) aged up to 18 years. ...

        Research

        Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births

        The positive association between caesarean section (CS) and autism spectrum disorder (ASD) may be attributed to preterm delivery. ...

        Research

        The relationship between maternal psychiatric disorder, autism spectrum disorder and intellectual disability in the child: a composite picture

        Research conducted by this laboratory has previously published four papers examining the relationship between maternal psychiatric disorders and having a... ...

        Research

        Evidence for shared deficits in identifying emotions from faces and from voices in autism spectrum disorders and specific language impairment

        While autism spectrum disorder (ASD) and specific language impairment (SLI) have traditionally been conceptualized as distinct disorders, recent findings... ...

        Research

        Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank

        Maternal immune activation and prenatal maternal stress are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring. ...

        Research

        Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial

        The objectives of this study were to develop a stability-indicating high performance liquid chromatography assay for benzylpenicillin in pharmaceutical fluids, and to investigate the stability of (i) isotonic citrate-buffered BPC solutions at the clinically relevant concentration of 30 mg/mL, and (ii) low concentration citrate-buffered BPC intravenous infusions (5–30 μg/mL). ...

        Research

        Postinfectious Acute Cerebellar Syndromes in Children: A Nationally Ascertained Case Series From Australia 2013–2018

        Postinfectious acute cerebellar syndromes show a wide spectrum of acute severity and can occur with acute febrile illness or vaccine receipt. Varicella has historically been the most common cause, associated with up to 25% of cases in large cohorts. This study aimed to describe the spectrum of syndromes in a setting with high varicella vaccine coverage. ...

        Research

        Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis

        Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. ...

        Research

        Placental Transcription Profiling in 6–23 Weeks’ Gestation Reveals Differential Transcript Usage in Early Development

        The human placenta is a rapidly developing transient organ that is key to pregnancy success. Early development of the conceptus occurs in a low oxygen environment before oxygenated maternal blood begins to flow into the placenta at ~10–12 weeks’ gestation. This process is likely to substantially affect overall placental gene expression. Transcript variability underlying gene expression has yet to be profiled. ...

        Research

        The Bone Marrow Microenvironment in B-Cell Development and Malignancy

        B lymphopoiesis is characterized by progressive loss of multipotent potential in hematopoi-etic stem cells, followed by commitment to differentiate into B cells, which mediate the humoral response of the adaptive immune system. ...

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