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        Research

        MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63

        We hypothesized that reactivation of p53 by inhibition of its negative regulator will result in p53-mediated growth arrest and apoptosis. ...

        Research

        Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in children

        The aim was to document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children ...

        Research

        Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes

        AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment. ...

        Research

        Early detection of lung function abnormalities in young children with cystic fibrosis

        In this review, we have examined the role of lung function testing in infants and preschool children with CF. ...

        Research

        Western Australian emergency department presentations related to child maltreatment and intentional injury

        To determine the proportion of child maltreatment-related emergency department presentations in WA and describe the types of injuries associated with them. ...

        Research

        Initial assessment of the StepWatch Activity Monitor™ to measure walking activity in Rett syndrome

        In girls and women with Rett syndrome, we assessed the accuracy of the StepWatch Activity Monitor™ and investigated relationships between daily step counts,... ...

        Research

        Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma

        The objective of this study was to examine the influence of viral respiratory infection (VRI) on treatment response in acute asthma in children. ...

        Research

        Peptides targeting the mitogen-activated protein kinase pathway (JNK/JUN) fail to reduce infarct volume after permanent MCAO in sprague dawley rats

        In this study we have assessed the ability of two TAT-fused peptides to reduce infarct volume and improve functional outcome following permanent ischaemia. ...

        Research

        Sugar sweetened beverage consumption by Australian children: Implications for public health strategy

        High consumption of sugar sweetened beverages (SSBs) has been linked to unhealthy weight gain and nutrition related chronic disease. ...

        Research

        Kawasaki disease, childhood allergy and the hygiene hypothesis

        Kawasaki disease is characterized by increased inflammation ...

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