Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

People having close contact with drug-resistant tuberculosis (DR-TB) patients are at increased risk of contracting and developing the disease. However, no comprehensive review has been undertaken to estimate the burden of DR-TB among contacts of DR-TB patients. Therefore, the current systematic review will quantify the prevalence and incidence of DR-TB among contacts of DR-TB patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

Tuberculosis (TB) is the leading infectious cause of death globally. Several preventive measures are employed to prevent TB, yet there is a paucity of evidence on the effectiveness of these interventions. Therefore, this study aimed to identify the most effective interventions for reducing TB incidence. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

The induction of DNA damage has been employed as an anticancer strategy for more than 100years, first starting with the use of radiation to treat stomach cancer followed by the first uses of DNA-damaging chemotherapy to treat childhood leukemia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Planetary health provides a perspective of ecological interdependence that connects the health and vitality of individuals, communities, and Earth's natural systems. It includes the social, political, and economic ecosystems that influence both individuals and whole societies. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

There is a global trend towards place-based initiatives (PBIs) to break the cycle of disadvantage and promote positive child development. Co-location is a common element of these initiatives and is intended to deliver more coordinated services for families of young children. This paper examines how co-locating early childhood services (ECS) from health and education in Child and Family Centres (CFCs) has impacted collaboration between services. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

In this. i study the MTD and RP2D, safety, PK, and preliminary activity of single-agent ribociclib were investigated in patients with neuroblastoma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

This research focuses on three questions 1) What are the patterns of stability & change; 2) what are the predictors of this progression, and; 3) what is the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• September 2015

Researchers conducting program evaluations in other contexts are advised to consider testing for this potential source of bias in their studies ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Parent–child book reading interventions alone are unlikely to meet needs of children and families for whom the absence of reading is psychosocial risk factor ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• November 2016