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        Research

        Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

        This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells ...

        Research

        Hospital admissions in children with developmental disabilities from ethnic minority backgrounds

        Children with CP and intellectual disability, particularly from minority backgrounds, were at higher risk of being admitted to hospital after the first year of life ...

        Research

        Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

        We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues ...

        Research

        Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease

        We report for the first time that a common stress condition, such as viral infection, can exacerbate mitochondrial dysfunction in a genetic model of mitochondrial disease ...

        Research

        Antibiotic appropriateness and guideline adherence in hospitalized children: results of a nationwide study

        Inappropriate antimicrobial prescribing in children was linked to specific risk factors, presenting opportunities for targeted interventions to improve prescribing ...

        Research

        Fetal alcohol spectrum disorder: the importance of assessment, diagnosis and support in the Australian justice context

        The current article outlines how individuals with fetal alcohol spectrum disorder may experience inequities within the justice system ...

        Research

        A structure-function analysis of interspecies antagonism by the 2-heptyl-4-alkyl-quinolone signal molecule from Pseudomonas aeruginosa

        Here we show that antibacterial activity of 4-hydroxy-2-heptylquinoline against Vibrionaceae is species-specific ...

        Research

        Meningococcal B vaccine and meningococcal carriage in adolescents in Australia

        Among Australian adolescents, the 4CMenB vaccine had no discernible effect on the carriage of disease-causing meningococci, including group B ...

        Research

        PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

        Our findings define PTPN2 as a target for bolstering T-cell-mediated anti-tumour immunity and CAR T-cell therapy against solid tumours. ...

        Research

        Genome mining and characterisation of a novel transaminase with remote stereoselectivity

        Here we report a novel ω-transaminase discovered in a marine sponge Pseudovibrio sp. isolate ...

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