B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM+ B cell subsets in healthy controls. For females with MS or CIS, significantly lower CD32b expression was identified on IgM+ B cell subsets, including naive and IgMhi MZ-like B cells, when compared with control females. Lower CD32b expression on these B cell subsets was associated with detectable anti-Epstein Barr Virus viral capsid antigen IgM antibodies, and higher serum levels of B cell activating factor. To investigate the effects of lower CD32b expression, B cells were polyclonally activated in the presence of IgG immune complexes, with or without a CD32b blocking antibody, and the expression of TNF and IL-10 in B cell subsets was assessed. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

These results indicate that anaphylaxis is not a major cause of adverse reactions to benzathine penicillin G ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

In this review, we consider recent evidence regarding hypoxia and sterile inflammation in cystic fibrosis airways ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• May 2016

Free NE activity is deleterious for epithelial homeostasis and support the hypothesis that proteases in the airway contribute to CF structural lung disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Graham Shannon Elizabeth Hall Simpson Smith GL SS ES BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (hons), PhD PhD, MSc, BSc Honorary Research ...

• 1. Telethon Kids Institute
• Projects

Hannah Peter Moore Richmond HC PC OAM BSc (Hons) GradDipClinEpi PhD MBBS MRCP(UK) FRACP Program Head, Infection and Vaccines Head, Vaccine Trials ...

• 1. Telethon Kids Institute
• Projects

Rosemary Sophie Jonathan Wyber La Vincente Carapetis AM R SLV JR MBChB MPH FRACGP PhD BPsych (Hons) MAppEpi PhD AM MBBS FRACP FAFPHM PhD FAHMS Senior ...

• 1. Telethon Kids Institute
• Projects

Alexander David Deborah Larcombe Martino Strickland A DM DH BScEnv (Hons) PhD BSc PhD PhD Team Leader, Respiratory Environmental Health Head, ...

• 1. Telethon Kids Institute
• Projects