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        Research

        Tackling the Burden of Osteoarthritis as a Health Care Opportunity in Indigenous Communities-A Call to Action

        Osteoarthritis is a highly prevalent and disabling disease, causing a significant individual and socioeconomic burden worldwide. Until now, there has been a dearth of research exploring the impact of osteoarthritis in global Indigenous communities. ...

        Research

        Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia

        In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

        Research

        Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

        Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained ...

        Research

        Prebiotics: mechanisms and preventive effects in allergy

        In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention ...

        Research

        Impact of Childhood Pneumococcal Conjugate Vaccine on Nonnotified Clinically Suspected Invasive Pneumococcal Disease in Australia

        This study provides a quantitative estimate of the total burden of invasive pneumococcal disease preventable by vaccination programs in Australia ...

        Research

        The pervasive effects of timing of parental mental health disorders on adolescent deliberate self-harm risk

        This study shows that timing is important for understanding intergenerational transmission of deliberate self-harm risk ...

        Research

        Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study

        Higher UVR exposure at antigen sensitization was associated with a reduced delayed-type hypersensitivity response and altered T helper type 17 kinetics ...

        Research

        Overcrowded housing: One of a constellation of vulnerabilities for child sexual abuse

        The findings suggest that overcrowded living conditions are associated with an increased risk of sexual abuse for some children ...

        Research

        Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens

        These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control ...

        Research

        MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions

        These results suggest that the expression of miR-143, miR-210, and miR-200c in PE cells might provide a signature for diagnosing malignant pleural mesothelioma ...

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