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        Research

        Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

        Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide). ...

        Research

        The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

        Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

        Research

        Differences in stroke risk and cardiovascular mortality for Aboriginal and other Australian patients with atrial fibrillation

        Stroke risk and cardiovascular mortality are markedly higher for Aboriginal than non-Aboriginal patients with atrial fibrillation, particularly for patients under 60 ...

        Research

        Perinatal risk factors associated with skin infection hospitalisation in Western Australian Aboriginal and Non-Aboriginal children

        We have quantified the relative influence of perinatal risk factors associated with skin infection hospitalisations in WA children ...

        Research

        The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

        Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

        Research

        Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

        This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of chronic lung diseases ...

        Research

        Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

        These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease ...

        Research

        Missing Voices: Profile, Extent, and 12-Month Outcomes of Nonfatal Traumatic Brain Injury in Aboriginal and Non-Aboriginal Adults in Western Australia

        These findings suggest an urgent need for multisectoral primary prevention of traumatic brain injury ...

        Research

        Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

        To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

        Research

        Physician training programs significantly improve diagnosis in cases coded as anaphylaxis over time: A major factor compounding time-trend data?

        Recent studies based on hospital admissions have reported a significant increase in anaphylaxis prevalence. ...

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