Infectious diseases such as tuberculosis (TB), malaria and soil-transmitted helminthiasis continue to impose a significant global health burden and socio-economic impact. Globally, minority indigenous people are disproportionately affected by poverty and are shown to experience a disparate burden of disease and poorer health outcomes than the comparative majority population. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2021
• July 2021

The greatest barrier to addressing the social determinants of health in the pediatric context is the dominance of the 'medical model' of care ...

• 1. Telethon Kids Institute
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• 2017
• November 2017

Collaborating Institutions Investigators Advocacy: END RHD Chief Investigators Professor Jonathan Carapetis AM Professor Dawn Bessarab Professor Alex ...

• End Rheumatic Heart Disease Centre of Research Excellence

Co-Head, Children's Lung Health; Senior Research Fellow ...

• 1. Telethon Kids Institute
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Lung function testing and lung imaging are commonly used techniques to monitor respiratory diseases, such as cystic fibrosis (CF). The nitrogen (N2) multiple-breath washout technique (MBW) has been shown to detect ventilation inhomogeneity in CF, but the underlying pathophysiological processes that are altered are often unclear. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2023
• Jun 2023

The review examines the international literature to determine how disengagement can be defined & understood, & then examines student disengagement in Australia. ...

• 1. Telethon Kids Institute
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• 2015
• October 2015

Collaborating Institutions Investigators Chief Investigators Professor Jonathan Carapetis AM Professor Dawn Bessarab Professor Alex Brown Professor ...

• 1. Telethon Kids Institute
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• Early Environment
• END RHD Program
• RHD in Australia

The D-Light program, set up in 2014, aims to shed light on the amount of sun exposure that will promote good health in children and adolescents. ...

• 1. Telethon Kids Institute
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• 2016
• May

Rishi Sury Laurence Sébastien Kotecha Cheung Malinge RS LC SM MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD PhD Co-Head, Leukaemia ...

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DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021