Embrace @ Telethon Kids Institute celebrates Wear It Purple Day with Rio Tinto ...

• Embrace @ Telethon Kids
• News and events
• 2023

Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region. However, Plasmodium falciparum parasites partially resistant to sulfadoxine-pyrimethamine (with quintuple mutations) potentially threaten the protective effectiveness of SMC. We evaluated the spread of quintuple-mutant parasites and the clinical consequences.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• July 2024

The Cardiometabolic Sunhealth team are committed to better understanding the influence that sun exposure has on our health (both positive and negative) and its potential to be used as part of therapies or preventative strategies. ...

• 1. Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Diabetes, Metabolism and Clinical Sciences

Determine the effectiveness of 6 months' closed-loop compared with manually determined insulin dosing on time-in-target glucose range in adults with type 1 diabetes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

A new research scholarship to combat childhood brain tumours will be launched tonight in honour of two year old Perth toddler Ethan Davies. ...

• 1. Telethon Kids Institute
• News & Events
• News & Events at Telethon Kids
• 2012
• September

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to developing leukemia, especially B cell acute lymphoblastic leukemia (B-ALL), the HSA21 genes that contribute to malignancies remain largely undefined. Here, we report that DYRK1A is overexpressed and required for B-ALL. Genetic and pharmacologic inhibition of DYRK1A decreased leukemic cell expansion and suppressed B-ALL development in vitro and in vivo. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

A contemporary, well-validated instrument for the measurement of behavior change in children after general anesthesia is lacking. The Post Hospitalization Behavior Questionnaire for Ambulatory Surgery (PHBQ-AS) has been developed as an updated version of the original Post Hospitalization Behavior Questionnaire (PHBQ) to better reflect the current patient population and modern anesthetic practices. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

The objective was to conduct a comprehensive economic and health services assessment of the frequency, duration, and cost of hospital admissions during the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• September 2014

BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Hypoactive delirium is present when an awake child is unaware of his or her surroundings, is unable to focus attention, and appears quiet and withdrawn. This condition has been well-described in the intensive care setting but has not been extensively studied in the immediate post-anesthetic period. The aim was to determine if hypoactive emergence delirium occurs in the recovery unit of a pediatric hospital, and if so, what proportion of emergence delirium is hypoactive in nature. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021