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        81-90 of 220 results for 'animal research'

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        Research Assistant - Leukaemia Research

        We are a collaborative group focused on improving outcomes for children with leukaemia. The Research Assistant will evaluate novel therapeutics in ...

        PhD - Respiratory Environmental Health / Public Health

        This PhD Scholarship will support an exceptional new PhD student to undertake research at the Telethon Kids Institute and Curtin University within ...

        Research

        Illuminating mitochondrial translation through mouse models

        Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial genome encodes 11 mRNAs encoding 13 OXPHOS proteins along with 2 rRNAs and 22 tRNAs, that facilitate their translation on mitoribosomes. ...

        Research

        Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

        Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemotherapy is widely used in combination with immune checkpoint blockade (ICB). Although a variety of isolated immunostimulatory effects have been reported for several classes of chemotherapeutics, it is unclear which chemotherapeutics provide the most benefit when combined with ICB. ...

        Research

        Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

        Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways. ...

        Research

        Effect of amino acid polymorphisms of house dust mite Der p 2 variants on allergic sensitization

        Measures of allergic sensitization and therapeutic strategies could be optimized with knowledge of Der p 2 variants ...

        Research

        Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and C

        Our results indicate a dissociation between the antibody and T-cell responses to rhinoviruses ...

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        Every Thursday: Discussion & Technical Seminar Series

        Improving health outcomes for pregnant women with allergic asthma and their babies: Thursday 22nd May. ...

        Research

        Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life

        Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. ...

        Research

        Living with lung disease: experimental models to assess the long-term effects of prematurity

        Laboratory models provide an important tool in helping to understand the cellular and molecular drivers of respiratory disease. Many animal models exist that model the neonatal outcomes of preterm birth. ...

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