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        Research

        Tissue resident memory T cells: putting cancer cells to sleep and a target for therapy

        Alison McDonnell AM BSc (Hons), PhD Early Career Fellow alison.mcdonnell@telethonkids.org.au Early Career Fellow Dr Alison McDonnell is a ...

        Research

        Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

        The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations. ...

        Research

        Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity

        There has been a coordinated effort from academic institutions and the PI to identify biomarkers that can predict immune checkpoint blockade response in cancer. ...

        Research

        Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

        Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited. ...

        Research

        A surveillance clinic for children and adolescents with, or at risk of, hereditary cancer predisposition syndromes

        Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation. ...

        Research

        Deregulated expression of connective tissue growth factor is linked to poor outcome in human cancer

        Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers. The role it plays in these neoplasms is diverse and tumour specific. ...

        The evolution of one of Australia's leading cancer research centres

        Odds are, you've never heard of Geoff Cattach. He's not unhappy about that. Yet for the past 30 years, Geoff has headed the Children's Leukaemia and ...

        News & Events

        Raine Foundation grants support exciting projects in childhood cancer and newborn infections

        Two Telethon Kids Institute researchers have been awarded prestigious grants from the Raine Medical Research Foundation for projects in childhood cancer and newborn infection control. ...

        News & Events

        Cheers as Beau’s curls cut to fund cancer fight

        A brave young man stepped up to the plate on Friday to do his part in the battle against cancer. ...

        News & Events

        Telethon Kids researchers share in $1.75m ACRF grant for cancer research

        Three Telethon Kids researchers are collaborating on a cancer research project that has been awarded a $1.75mill grant by the Australian Cancer Research Fund. ...

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