The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on the trait. The genetic architecture is complex, heterogeneous, and multifactorial, but investigations of contributions of single-nucleotide polymorphisms (SNPs) were thus far underpowered. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Emerging research suggests that maternal immune activation (MIA) may be associated with an increased risk of adverse neurodevelopmental and mental health outcomes in offspring. Using data from the Raine Study, we investigated whether MIA during pregnancy was associated with increased behavioral and emotional problems in offspring longitudinally across development. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Developmental theory and previous studies support the potential value of prodromal interventions for infants at elevated likelihood of developing autism. Past research has supported the efficacy of parent-mediated prodromal therapies with infants from as early as 7 months. We outline the rationale for implementing interventions following this model from even earlier in development and report on the feasibility of a novel intervention developed following this model of parent-mediated infant interventions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

Greater facial asymmetry has been consistently found in children with autism spectrum disorder (ASD) relative to children without ASD. There is substantial evidence that both facial structure and the recurrence of ASD diagnosis are highly heritable within a nuclear family. Furthermore, sub-clinical levels of autistic-like behavioural characteristics have also been reported in first-degree relatives of individuals with ASD, commonly known as the 'broad autism phenotype'. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

Anaesthetic dose causing toxicity in animals has been evaluated, but the relationship between duration of VA exposure and development in children remains vague. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

This is the first study demonstrating facial hypermasculinisation in ASD and its relationship to social-communication difficulties in prepubescent children ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• March 2015

To investigate use patterns and learning outcomes associated with the use of Therapy Outcomes By You (TOBY. Playpad, an early intervention iPad application. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

In this paper we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• September 2014

This finding supports distinct cognitive profiles in ASD and SLI and may provide further evidence for distinct aetiological mechanisms in the two conditions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013