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        Research

        Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

        Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

        Over 200 million reasons to be grateful for golf - the birth of Telethon

        In 1967, on the perfectly manicured greens of the exclusive Lake Karrinyup Country Club, a golf game between mates was to lead to the birth of one of ...

        News & Events

        Control IQ

        Control IQ (CIQ) is an advanced hybrid closed loop system designed to ease the burden and stress involved in the daily decision making around diabetes management. ...

        News & Events

        How to support your kids through the next phase of COVID-19

        In Western Australia we have so far been remarkably successful in flattening the curve and preventing the community spread of COVID-19. ...

        News & Events

        Starting or returning to school after the holidays

        The transition to school can be an exciting but also uncertain time for children and families. We know many children with autism may be more sensitive to transitions so may need some extra supports at this time. ...

        News & Events

        ORIGINS Project shines light on Early Childhood Development

        A collaboration between the Telethon Kids Institute and Joondalup Health Campus is poised to be a game-changer for early childhood development. ...

        News & Events

        Childcare centres urged to adopt new policy to boost kids’ physical activity

        Childcare centres will be invited to help boost children’s physical activity levels by signing on to a new program which commits them to creating more opportunities for physical activity. ...

        News & Events

        Delivering smart drugs into cells

        The Drug Discovery Unit has been finding ways for smart drugs to penetrate deep into cells and attacking their disease targets while causing fewer side effects ...

        News & Events

        Families flock outdoors to find COVID silver lining

        A Telethon Kids Institute study which looked at how Western Australian families coped with COVID-19 restrictions has shown many parents managed to find the silver lining in WA’s lockdown last year. ...

        Research

        Meeting the Australian 24-Hour Movement Guidelines for the Early Years is associated with better social-emotional development in preschool boys

        24-hour Movement Guidelines for the Early Years promote that achieving all three-movement behaviour (sleep, sedentary behaviour and physical activity) recommendations is important for child health and development. We examined the association between meeting all, none and combinations of the Australian 24-Hour Movement Guidelines for the Early Years and social-emotional development in 1363 preschool (2-5 years) boys (52%) and girls. ...

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