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        Research

        Metabolic dysfunction induced by a high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

        Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high-fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)-which give rise to DCs-in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the 'whitening' effect of eating a high-fat diet upon interscapular (i) BAT of mice. ...

        Research

        Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

        The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. ...

        Research

        Distinguishing benign from pathologic TH2 immunity in atopic children

        In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor ...

        Research

        Risk Factors for Gut Dysbiosis in Early Life

        Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbiosis of the intestinal microbiota can have a substantial effect on the nervous and immune systems, contributing to the onset of several inflammatory diseases. ...

        Research

        Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice

        To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established. ...

        Research

        Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations

        Atopic asthma, which is at its highest prevalence during childhood/young adulthood, represents the main focus of this review. ...

        Research

        The role of dendritic cells and regulatory T cells in the regulation of allergic asthma

        Airways hyperresponsiveness (AHR) is one of the major clinical features of allergic airways disease including allergic asthma ...

        Research

        An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

        Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

        Research

        Targeting the mucosal immune system in a mouse model to prevent pregnancy complications following maternal bacterial infection

        Susan Pat Deborah Prescott Holt Strickland SL PG DH MBBS BMedSci PhD FRACP PhD, DSc, FRCPath, FRCPI, FAA PhD Honorary Research Fellow Emeritus ...

        Research

        In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection

        Respiratory syncytial virus (RSV) causes annual epidemics of infections affecting the whole population. In vitro, it has been shown to infect and persist in human dendritic cells (DCs) for prolonged periods. Initially persistence is associated with low levels of replication before the virus becomes dormant. Reactivation of viral replication can be triggered many months later. ...

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