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        Allergy, Inflammation & Immunity

        ORIGINS has several sub-projects exploring allergy development within the cohort, with a focus on nutritional strategies for allergy prevention. ...

        Research

        Vulnerable from the first breath - epithelial dysfunction and respiratory outcomes in children

        Anthony David Stephen Susan Kicic Martino Stick Prescott A DM SM SL BSc (Hons) PhD BSc PhD MB BChir PhD MRCP FRACP MBBS BMedSci PhD FRACP Rothwell ...

        News & Events

        Execution of Licence Agreement with Telethon Kids Institute and Erasmus University Medical Centre

        Resonance Health Ltd is pleased to announce that it has entered into a licence agreement with the Telethon Kids Institute and the Erasmus University Medical Centre. ...

        Research

        Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

        Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. ...

        Research

        Examining relationships between vitamin D over the first decade of life and development of asthma and allergy

        Pat Prue Holt Hart PG PH PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) MSc PhD Emeritus Honorary Researcher Head, Inflammation Patrick.Holt@ ...

        Research

        Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

        Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

        Research

        Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitis

        Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants ...

        Research

        Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea

        We aimed to explore whether newborns in high-risk areas have pre-existing pneumococcal-specific cellular immune responses that effects early acquisition. ...

        Research

        OPTIMUM: OPTimising IMmunisation Using Mixed schedules

        Pat Peter Susan Tom Jennifer Holt Richmond Prescott Snelling Kent PG PC SL T J PhD, DSc, FRCPath, FRCPI, FAA MBBS MRCP(UK) FRACP MBBS BMedSci PhD ...

        Research

        Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies

        Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear. ...

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