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        Research

        Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking

        Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for in utero cigarette smoke exposure. ...

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        Professor Christopher Blyth

        Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Honorary and NHMRC Career Development Fellow, Paediatric Infectious Diseases Physician and Clinical Microbiologist ...

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        2015 Seed Funding Recipients

        Eight applicants were successful, and were awarded $15,000 each for activities supporting subsequent research grant applications. (in alphabetical ...

        Attendance at a preschool program

        Policy Context Indicator Information View the Maps Educational institutions for children aged 0-4 years are structured, play-based learning programs ...

        News & Events

        Up and at ’em: Telethon Kids physical activity researcher named a WA Young Tall Poppy

        A Telethon Kids Institute researcher focused on promoting more active childhoods to improve child health and wellbeing will be named amongst WA’s most outstanding young scientists at the upcoming 2020 Young Tall Poppy Science Awards. ...

        News & Events

        AEDC translation toolkit helps schools help kids

        A toolkit designed to help schools use AEDC data to inform planning of early childhood programs and encourage engagement with the broader early childhood community is making a difference. ...

        Research

        Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy

        In children with Prader-Willi syndrome (PWS), growth hormone (GH) improves height and body composition; however, may be associated with worsening sleep-disordered breathing (SDB). Some studies have reported less SDB after GH initiation, but follow-up with polysomnography is still advised in most clinical guidelines. ...

        Research

        How Well Does the EQ-5D-Y-5L Describe Children With Intellectual Disability?: “There's a Lot More to My Child Than That She Can't Wash or Dress Herself.”

        The EQ-5D-5L is a generic health utility instrument for measuring health-related quality of life (HRQoL), with self-report and proxy report versions for children (EQ-5D-Y-5L). Children with intellectual disability (ID) are a heterogeneous population whose impairments and comorbidities place them at risk of poor HRQoL. This study aimed to describe the content validity and suitability for children with ID of a proxy report version of the EQ-5D-Y-5L as seen by their caregivers. ...

        News & Events

        MRCF launches Perth-based biotech developing new treatment for Cystic Fibrosis

        A Telethon Kids Institute spin-off company has received $20 million from the Medical Research Commercialisation Fund to develop a promising new therapy for the treatment of Cystic Fibrosis. ...

        Research

        Devising a Missing Data Rule for a Quality of Life Questionnaire - A Simulation Study

        The aim of this study was to devise an evidence-based missing data rule for the Quality of Life Inventory-Disability (QI-Disability) questionnaire specifying how many missing items are permissible for domain and total scores to be calculated using simple imputation. ...

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