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        Research

        Understanding the aetiology and resolution of chronic otitis media from animal and human studies

        This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition ...

        Research

        Pneumococcal responses are similar in Papua New Guinean children aged 3-5 years vaccinated in infancy with pneumococcal polysaccharide vaccine with or without prior pneumococcal conjugate vaccine, or without pneumococcal vaccination

        We studied in a non-randomized follow-up trial the persistence of pneumococcal immunity in children, 3-5 years of age, in community controls of a similar age. ...

        Research

        Increased CTLA-4+ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary disease

        Chronic inflammation may expand sub-populations of T cells expressing CTLA-4 in COPD patients and therefore impair T-cell function ...

        Research

        Self-harm: Prevalence estimates from the second Australian Child and Adolescent Survey of Mental Health and Wellbeing

        The demonstrated higher risks in young people for continued harm or possible death support the need for ongoing initiatives to reduce self-harm ...

        Research

        Late-talking and risk for behavioural and emotional problems during childhood and adolescence

        Although many toddlers with expressive vocabulary delay ("late talkers") present with age-appropriate language skills by the time they are of school age... ...

        Research

        Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis

        We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation... ...

        Research

        Setting the RECORD straight: Developing a guideline for the reporting of studies conducted using observational routinely collected data

        There has been a dramatic increase in the availability of "routine data" for research purposes, including data from electronic medical records,... ...

        Research

        The changing epidemiology of invasive pneumococcal disease

        We investigated trends in invasive pneumococcal disease (IPD) in Western Australia (WA). ...

        Research

        Diverging Trends in Gastroenteritis Hospitalizations during Two Decades in Western Australian Aboriginal and Non-Aboriginal Children

        Our findings highlight the need to consider age, ethnicity, seasonality and climate when evaluating rotavirus vaccine programs. ...

        Research

        Impact of adolescent peer aggression on later educational and employment outcomes in an Australian cohort

        This study used prospective birth cohort data to analyse the relationship between peer aggression at 14 years of age and educational and employment outcomes... ...

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