Our mission Every year across the world, 3 million children are stillborn, 800,000 newborns die from infection and 15 million babies are born ...

A UNIQUE APPROACH... Our current projects   With unparalleled expertise in systems biology, the Born Strong Initiative can augment existing studies, ...

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• 1. Telethon Kids Institute
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Understanding if ongoing inflammation in the lungs contributes to the poor lung health experienced by some children who were born preterm. ...

• 1. Telethon Kids Institute
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Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

The European Respiratory Society Oscillometry Taskforce identified that clinical correlates of bronchodilator responses are needed to advance oscillometry in clinical practice. The understanding of bronchodilator-induced oscillometry changes in preterm lung disease is poor. Here we describe a comparison of bronchodilator assessments performed using oscillometry and spirometry in a population born very preterm and explore the relationship between bronchodilator-induced changes in respiratory function and clinical outcomes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

Children born preterm have impaired lung function and altered lung structure. However, there are conflicting reports on how preterm birth impacts aerobic exercise capacity in childhood. We aimed to investigate how neonatal history and a diagnosis of bronchopulmonary dysplasia (BPD) impact the relationship between function and structure of the lung, and aerobic capacity in school-aged children born very preterm. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Expiratory flow limitation is more prevalent in children born preterm with bronchopulmonary dysplasia and is associated with airway obstruction ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

This review aims to summarise what is known about the long-term pulmonary outcomes of contemporary preterm birth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Exhaled breath condensate (EBC) collection is a non-invasive, safe method for measurement of biomarkers in patients with lung disease. Other methods of obtaining samples from the lungs, such as bronchoalveolar lavage, are invasive and require anaesthesia/sedation in neonates and infants. EBC is particularly appealing for assessing biomarkers in preterm-born infants, a population at risk of ongoing lung disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022