Aleksandra Filipovska AF BSc PhD Louis Landau Chair in Child Health Research; NHMRC Leadership Fellow; Deputy Director, ARC Centre of Excellence for Synthetic Biology; Adjunct Research Professor, Monash University Louis Landau Chair in Child Health ...

• 1. Telethon Kids Institute
• Projects

The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• December 2013

Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukaemia (ALL). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

The MACROD2 gene is a strong positional candidate risk factor for autistic-like traits in the general population ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

The effect of breast-feeding on the development of allergic disease is uncertain ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by diverse genomic alterations, the most frequent being gene fusions detected via transcriptomic analysis (mRNA-seq). Due to its hypervariable nature, gene fusions involving the Immunoglobulin Heavy Chain (IGH) locus can be difficult to detect with standard gene fusion calling algorithms and significant computational resources and analysis times are required. We aimed to optimize a gene fusion calling workflow to achieve best-case sensitivity for IGH gene fusion detection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

This study examines whether polymorphisms in the ERBB2 gene were associated with leprosy in primary and replication cohorts from northeastern Brazil. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

Machine learning (ML) algorithms are powerful tools that are increasingly being used for sepsis biomarker discovery in RNA-Seq data. RNA-Seq datasets contain multiple sources and types of noise (operator, technical and non-systematic) that may bias ML classification. Normalisation and independent gene filtering approaches described in RNA-Seq workflows account for some of this variability and are typically only targeted at differential expression analysis rather than ML applications. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

We describe a cost-effective tag single nucleotide polymorphism approach using a multiplexed genotyping assay with mass spectrometry ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• July 2014